Title:
薬物送達デバイス
Document Type and Number:
Japanese Patent JP5833727
Kind Code:
B2
Abstract:
The invention provides an implantable intracranial device for the site-specific delivery of a pharmaceutically active agent to a human or animal for treating a mental or neurological disorder, such as Alzheimer's disease, schizophrenia or other psychoses. The biodegradable device includes a pharmaceutically active agent for treating the disorder, polymeric nano-lipoparticles into or onto which the pharmaceutically active agent is embedded; and a polymeric matrix or scaffold incorporating the nano-lipoparticles. The nano-lipoparticles can be in the form of nano-liposhells or nano-lipobubbles. The nano-liposhells or nano-lipobubbles can include an essential fatty acid or can be conjugated to a peptide ligand which targets the device to a specific cell into which the therapeutic agent can be delivered. The device can be implanted in the sub-arachnoid space in the region of the frontal lobe of the brain.
Inventors:
Gobender, silesen
Pirey, Vines
Tunara, Yahya Esopp
Du Tois, Lisa Claire
Modi, Greek
Nido, Dinesh
Mufamadi, Marta Stephen
Pirey, Vines
Tunara, Yahya Esopp
Du Tois, Lisa Claire
Modi, Greek
Nido, Dinesh
Mufamadi, Marta Stephen
Application Number:
JP2014216162A
Publication Date:
December 16, 2015
Filing Date:
October 23, 2014
Export Citation:
Assignee:
UNIVERSITY OF THE WITWATERSRAND, JOHANNESBURG
International Classes:
A61K47/38; A61K9/00; A61K9/48; A61K31/202; A61K31/5415; A61K45/00; A61K47/12; A61K47/34; A61P25/18
Domestic Patent References:
| JP2008133286A | ||||
| JP2007517902A | ||||
| JP2002502813A |
Foreign References:
| WO2010061288A1 |
Other References:
Journal of Pharmacy and Pharmacology,2010年10月,Vol.62, No.10,p.1243-1244
International Journal of Pharmaceutics,2004年,Vol.278,p.1-23
International Journal of Pharmaceutics,2004年,Vol.278,p.1-23
Attorney, Agent or Firm:
Fukami patent office