Title:
嘔吐反応防止可能なホスホジエステラーゼ４阻害剤
Document Type and Number:
Japanese Patent JP5851631
Kind Code:
B2
Abstract:
The present invention relates to a kind of Phosphodiesterase 4 inhibitors without vomiting, which is compounds or a prodrugs or solvates represented by formula (I), R 1 is an independent methoxy, bromine and substituted aryl; X is an optionally substituted six-membered heterocyclic ring; Y is -(CH 2 ) n -, -NH(CH 2 ) n -, and-NH(CH 2 ) n -O-, wherein n is any value among 0, 1, 2 and 3; Z is an optionally substituted aromatic ring or an optionally substituted heteroaromatic ring. The present invention is relates to a kind of Phosphodiesterase 4 inhibitors without vomiting, which is a novel biphenyl series PDE4D inhibitor, and can be applied to treat depression and Alzheimer's disease, improve cognitive ability and avoid vomiting.
Inventors:
XU,Jiangping
Weekly swing
Weekly swing
Application Number:
JP2014550614A
Publication Date:
February 03, 2016
Filing Date:
August 25, 2012
Export Citation:
Assignee:
XU,Jiangping
International Classes:
A61K31/50; A61P25/24; A61P25/28; A61P43/00
Domestic Patent References:
| JP2000281660A |
Foreign References:
| WO2009067600A1 | ||||
| WO2007081995A1 | ||||
| US6479495 |
Attorney, Agent or Firm:
Susumu Ito
Yasushi Hasegawa
Osamu Shinoura
Yasushi Hasegawa
Osamu Shinoura