Title:
ビーズまたは他の捕捉物を用いた分子または粒子の超高感度検出
Document Type and Number:
Japanese Patent JP5860922
Kind Code:
B2
Abstract:
The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules or particles with respect to a plurality of capture objects. At least a portion of the plurality of capture objects may be spatially separated into a plurality of locations. A measure of the concentration of analyte molecules in a fluid sample may be determined, at least in part, on the number of reaction vessels comprising an analyte molecule immobilized with respect to a capture object. In some cases, the assay may additionally comprise steps including binding ligands, precursor labeling agents, and/or enzymatic components.
Inventors:
Duffy, David, Sea.
Ricin, David, M.
Walt, David, Earl.
Fournier, David
Kang, Chek
Ricin, David, M.
Walt, David, Earl.
Fournier, David
Kang, Chek
Application Number:
JP2014105431A
Publication Date:
February 16, 2016
Filing Date:
May 21, 2014
Export Citation:
Assignee:
QUANTERIX CORPORATION
International Classes:
G01N33/543; G01N37/00
Domestic Patent References:
| JP2009529658A |
Foreign References:
| WO2009029073A1 |
Other References:
RISSIN DAVID M,DIGITAL CONCENTRATION READOUT OF SINGLE ENZYME MOLECULES USING FEMTOLITER ARRAYS AND POISSON STATIST,NANO LETTERS,米国,AMERICAN CHEMICAL SOCIETY,2006年 3月 1日,V6 N3,P520-523
RISSIN DAVID M,DIGITAL READOUT OF TARGET BINDING WITH ATTOMOLE DETECTION LIMITS VIA ENZYME AMPLIFICATION IN FEMTOLI,JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,米国,AMERICAN CHEMICAL SOCIETY,2006年 5月17日,V128 N19,P6286-6287
RISSIN DAVID M,DIGITAL READOUT OF TARGET BINDING WITH ATTOMOLE DETECTION LIMITS VIA ENZYME AMPLIFICATION IN FEMTOLI,JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,米国,AMERICAN CHEMICAL SOCIETY,2006年 5月17日,V128 N19,P6286-6287
Attorney, Agent or Firm:
Kiyoji Kuzuwa
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