Title:
免疫組織染色法、およびこれを用いた抗体医薬の有効性を判定する方法
Document Type and Number:
Japanese Patent JP5900489
Kind Code:
B2
Abstract:
The purpose of the invention is to provide an immunohistological staining method which enables staining with high accuracy using an antibody preparation containing, as a component, an antibody such as trastuzumab as a substance which recognizes a target biological material, and also to provide a method for determining the effectiveness of an antibody preparation with high accuracy using such an immunohistological staining method. The invention provides an immunohistological staining method using an antibody which is a constituent component of an antibody preparation as a substance which recognizes an antigen to be targeted by the antibody preparation, and also provides a method for determining the effectiveness of the antibody preparation by measuring the binding amount of the antibody with respect to the amount of the antigen using the immunohistological staining method.
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Inventors:
Hideki Goda
Ning Nakano
Naohiro Okada
Kosuke Gonda
Takehiro Motohiro
Noriaki Ouchi
Ning Nakano
Naohiro Okada
Kosuke Gonda
Takehiro Motohiro
Noriaki Ouchi
Application Number:
JP2013507430A
Publication Date:
April 06, 2016
Filing Date:
March 21, 2012
Export Citation:
Assignee:
Konica Minolta Co., Ltd.
International Classes:
G01N33/53; G01N33/48; G01N33/536; G01N33/574
Domestic Patent References:
| JP2009509171A | 2009-03-05 | |||
| JP2010209314A | 2010-09-24 | |||
| JP2002501184A | 2002-01-15 | |||
| JP2006506943A | 2006-03-02 | |||
| JP2004352542A | 2004-12-16 | |||
| JP2010209314A | 2010-09-24 | |||
| JP2002501184A | 2002-01-15 | |||
| JP2009509171A | 2009-03-05 | |||
| JP2011252819A | 2011-12-15 |
Foreign References:
| WO2012029269A1 | 2012-03-08 | |||
| WO2012035705A1 | 2012-03-22 | |||
| US20100316635A1 | 2010-12-16 | |||
| WO2009028282A1 | 2009-03-05 | |||
| WO2012029342A1 | 2012-03-08 | |||
| WO2008041594A1 | 2008-04-10 | |||
| US20100316635A1 | 2010-12-16 | |||
| WO2009028282A1 | 2009-03-05 | |||
| WO2012029342A1 | 2012-03-08 | |||
| WO2012029269A1 | 2012-03-08 | |||
| WO2012035705A1 | 2012-03-22 |
Other References:
JPN6012018887; 生体超微細１ 分子可視化技術によるナノＤＤＳ とがん標的治療に関する研究 平成１８ 年度 総括・分担研究年度終
JPN6012018888; Ｍａｃｒｏｍｏｌｅｃｕｌａｒ Ｒｅｓｅａｒｃｈ， ２０１０．０７， Ｖｏｌ．１８， Ｎｏ．７， Ｐａｇｅ．６４１-６４７
JPN6012018889; 組織細胞化学， ２００６， Ｖｏｌ．２００６， Ｐａｇｅ．２５-３４
JPN6012018886; 臨床検査 Ｖｏｌ．５０， Ｎｏ．７， Ｐａｇｅ．７５３-７６０, 2006
JPN6012018887; 生体超微細１ 分子可視化技術によるナノＤＤＳ とがん標的治療に関する研究 平成１８ 年度 総括・分担研究年度終
JPN6012018888; Ｍａｃｒｏｍｏｌｅｃｕｌａｒ Ｒｅｓｅａｒｃｈ， ２０１０．０７， Ｖｏｌ．１８， Ｎｏ．７， Ｐａｇｅ．６４１-６４７
JPN6012018889; 組織細胞化学， ２００６， Ｖｏｌ．２００６， Ｐａｇｅ．２５-３４
JPN6016003703; ＢＡＫＡＬＯＶＡ Ｒｕｍｉａｎａ ｅｔ ａｌ．: 'Ｑｕａｎｔｕｍ ＤＯＴ-Ｂａｓｅｄ Ｗｅｓｔｅｒｎ Ｂｌｏｔ Ｔｅｃｈｎｏｌｏｇｙ ｆｏｒ Ｕｌｔｒａｓｅｎｓｉｔｉｖｅ Ｄｅｔｅｃｔｉｏｎ ｏｆ Ｔｒａｃｅｒ Ｐｒｏｔｅｉｎｓ' Ｊ Ａｍ Ｃｈｅｍ Ｓｏｃ Ｖｏｌ．１２７， Ｎｏ．２６, 2005, Ｐａｇｅ．９３２８-９３２９
JPN6012018888; Ｍａｃｒｏｍｏｌｅｃｕｌａｒ Ｒｅｓｅａｒｃｈ， ２０１０．０７， Ｖｏｌ．１８， Ｎｏ．７， Ｐａｇｅ．６４１-６４７
JPN6012018889; 組織細胞化学， ２００６， Ｖｏｌ．２００６， Ｐａｇｅ．２５-３４
JPN6012018886; 臨床検査 Ｖｏｌ．５０， Ｎｏ．７， Ｐａｇｅ．７５３-７６０, 2006
JPN6012018887; 生体超微細１ 分子可視化技術によるナノＤＤＳ とがん標的治療に関する研究 平成１８ 年度 総括・分担研究年度終
JPN6012018888; Ｍａｃｒｏｍｏｌｅｃｕｌａｒ Ｒｅｓｅａｒｃｈ， ２０１０．０７， Ｖｏｌ．１８， Ｎｏ．７， Ｐａｇｅ．６４１-６４７
JPN6012018889; 組織細胞化学， ２００６， Ｖｏｌ．２００６， Ｐａｇｅ．２５-３４
JPN6016003703; ＢＡＫＡＬＯＶＡ Ｒｕｍｉａｎａ ｅｔ ａｌ．: 'Ｑｕａｎｔｕｍ ＤＯＴ-Ｂａｓｅｄ Ｗｅｓｔｅｒｎ Ｂｌｏｔ Ｔｅｃｈｎｏｌｏｇｙ ｆｏｒ Ｕｌｔｒａｓｅｎｓｉｔｉｖｅ Ｄｅｔｅｃｔｉｏｎ ｏｆ Ｔｒａｃｅｒ Ｐｒｏｔｅｉｎｓ' Ｊ Ａｍ Ｃｈｅｍ Ｓｏｃ Ｖｏｌ．１２７， Ｎｏ．２６, 2005, Ｐａｇｅ．９３２８-９３２９
Attorney, Agent or Firm:
Patent corporation ssinpat