Title:
消化器障害を治療するための組成物および方法
Document Type and Number:
Japanese Patent JP5901291
Kind Code:
B2
Abstract:
Provided are electrokinetically-altered fluids (e.g., gas-enriched (e.g., oxygen-enriched) electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide, upon contact with a cell, modulation of at least one of cellular membrane potential and cellular membrane conductivity, and therapeutic compositions and methods for using same in treating digestive disorders or at least one symptom thereof. The electrokinetically altered fluid compositions and methods include electrokinetically-altered ionic aqueous fluids optionally in combination with other therapeutic agents. Particular aspects provide for regulating or modulating intracellular signal transduction associated with said digestive disorders by modulation of at least one of cellular membranes, membrane potential, membrane proteins such as membrane receptors, including but not limited to G-Protein Coupled Receptors (GPCR), and intercellular junctions (e.g., tight junctions, gap junctions, zona adherins and desmasomes). Other embodiments include particular routes of administration or formulations for the electrokinetically-altered fluids and therapeutic compositions.
Inventors:
Watson, Richard Elle.
Wood, Anthony Bee.
Archampsault, Gregory Jay.
Wood, Anthony Bee.
Archampsault, Gregory Jay.
Application Number:
JP2011507623A
Publication Date:
April 06, 2016
Filing Date:
April 29, 2009
Export Citation:
Assignee:
Rebalcio corporation
International Classes:
A61K33/00; A61K9/08; A61K31/341; A61K31/4433; A61K45/00; A61P1/00; A61P1/04; A61P43/00
Domestic Patent References:
| JP2004529090A | ||||
| JP2005246294A |
Other References:
TAYLOR,REGULATION OF INTESTINAL EPITHELIAL GENE EXPRESSION IN HYPOXIA,FOREF. IN NEPH.,KIDNEY INT.,2004年 8月,V66 N2,P528-531
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto