Title:
新規な多価免疫グロブリン
Document Type and Number:
Japanese Patent JP5924751
Kind Code:
B2
Abstract:
The present invention provides a multivalent immunoglobulin or part thereof binding specifically to at least two cell surface molecules of a single cell with at least one modification in at least one structural loop region of said immunoglobulin determining binding to an epitope of said cell surface molecules wherein the unmodified immunoglobulin does not significantly bind to said epitope, its use and methods for producing it.
Inventors:
Backpacker Florian
Himmler Gottfried
Votuniak-Knopp Goldana
Himmler Gottfried
Votuniak-Knopp Goldana
Application Number:
JP2009516813A
Publication Date:
May 25, 2016
Filing Date:
June 26, 2007
Export Citation:
Assignee:
F-Star Biotechnology Shu Forsungs-Und Entwick Lungsguez. M. B. Her.
International Classes:
C12N15/09; A61K39/395; A61P37/04; C07K16/28; C07K16/46; C12P21/08; G01N33/53
Foreign References:
| WO2006036834A1 |
Other References:
Clinical cancer research,2006 Jul 1,Vol12,No.13,p.4036-4042
Immunology today,1993,Vol.14,No.6,p.243-246
Acta pharmacologica Sinica,2005,Vol.26,No.6,p.649-658
Immunology today,1993,Vol.14,No.6,p.243-246
Acta pharmacologica Sinica,2005,Vol.26,No.6,p.649-658
Attorney, Agent or Firm:
Masayuki Masabayashi
Hayashi Ichiyoshi
Hayashi Ichiyoshi