Title:
ミスフォールドプリオンタンパク質を標的とする抗体および複合体
Document Type and Number:
Japanese Patent JP6430373
Kind Code:
B2
Abstract:
Human prion protein, PrP, selectively presents the epitope MDEYSNQNN (SEQ ID No. 14) when PrP misfolds. The misfolded form of human PrP is associated with various disease states. The present invention provides an antibody useful to detect and treat such diseases, including cancer such as ovarian cancer and lymphomas, and transmissible spongiform encephalopathies such as CJD. Also provided is an immunoconjugate in which the antibody is conjugated with urease as cytotoxin.
Inventors:
Marni, Diane, Uge
Bienton, Chai
Veronica, Chorphy
Neil, Earl. Cashman
Bao Ming, Tian
Wa, Yao, Wong
Himan, Rap-Man, Chao
Bienton, Chai
Veronica, Chorphy
Neil, Earl. Cashman
Bao Ming, Tian
Wa, Yao, Wong
Himan, Rap-Man, Chao
Application Number:
JP2015516391A
Publication Date:
November 28, 2018
Filing Date:
June 11, 2013
Export Citation:
Assignee:
PROMIS NEUROSCIENCES INC.
HELIX BIOPHARMA CORP.
HELIX BIOPHARMA CORP.
International Classes:
C07K16/18; A61K38/08; A61K38/10; A61K39/395; A61P25/00; A61P35/00; A61P35/02; A61P43/00; C07K7/06; C07K7/08; C07K7/14; C07K19/00; G01N33/53
Domestic Patent References:
| JP2012504801A | ||||
| JP2007502966A | ||||
| JP2003521477A |
Attorney, Agent or Firm:
Yukitaka Nakamura
Hirohito Katsunuma
Mari Asano
Hiroshi Sorimachi
Hirohito Katsunuma
Mari Asano
Hiroshi Sorimachi