Title:
薬剤注入装置を制御する制御装置を操作する方法
Document Type and Number:
Japanese Patent JP6446030
Kind Code:
B2
Abstract:
Method of operating a control device for controlling an infusion device A method of operating a control device (2) for controlling an infusion device (33) for administering a drug to a patient (P) comprises the steps of: providing a model (p) to predict a time-dependent drug concentration (Cplasma, Clung, Cbrain) in multiple compartments (A1-A5) of a patient (P); setting a target concentration value (CTbrain) to be achieved in at least one of the compartments (A1-A5) of the patient (P); determining a drug dosage (D1) to be administered to a first compartment (A1) of the multiple compartments (A1-A5) of the patient (P) using the model (p) such that the difference between the target concentration value (CTbrain) and a predicted steady-state drug concentration (Cplasma, Clung, Cbrain) in the at least one of the compartments (A1-A5) is smaller than a pre-defined threshold value (Ub-rain); providing a control signal (S1) indicative of the drug dosage (D1) to an infusion device (33) for administering the drug dosage (D1) to the patient (P); obtaining a measurement value (M1, M2) indicating a measured drug concentration in a second compartment (A2, A3) of the multiple compartments (A1-A5) at a measurement time (t1, t2); adjusting the model (p) such that the model (p) predicts a drug concentration (Clung, Cbrain) in the second compartment (A2, A3) at the measurement time (t1, t2) which at least approximately matches the measured drug concentration in the second compartment (A2, A3); and determining a new drug dosage (D2, D3) to be administered into the first compartment (A1) of the patient (P) using the model (p) such that the difference between the target concentration value (CT-brain) and a predicted steady-state drug concentration (Cplasma, Clung, Cbrain) in the at least one of the compartments (A1, A2, A3) is smaller than the predefined threshold value (Ubrain). In this way a method is provided which allows for an improved (personalized and predictive) control of a drug administration procedure, in particular when administering an anaesthetic drug such as Propofol and/or an analgesic drug such as Remifentanil within a procedure.
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Inventors:
Becker, michael
Application Number:
JP2016509331A
Publication Date:
December 26, 2018
Filing Date:
February 24, 2014
Export Citation:
Assignee:
Fresenius Carb Deutschland Game Behr
International Classes:
A61M5/168; A61M5/172; G16H20/17
Domestic Patent References:
| JP2008546435A | ||||
| JP3136666A | ||||
| JP2005514122A | ||||
| JP2002136596A | ||||
| JP2012515032A | ||||
| JP2005509465A | ||||
| JP2009540890A |
Attorney, Agent or Firm:
Katsuto Momii