Title:
非環式ヌクレオシドホスホン酸ジエステル
Document Type and Number:
Japanese Patent JP6462659
Kind Code:
B2
Abstract:
The present disclosure relates, inter alia, to a compound of Formula (la):
or a pharmaceutically acceptable salt thereof for use in treating human papilloma virus, cervical intraepithelial neoplasia, anal intraepithelial neoplasia, or vulvar intraepithelial neoplasia to a subject in need thereof wherein:
B Nuc ( a ) is selected from the group consisting of:
L a is an unsubstituted C 13-29 heteroalkyl;
R a is selected from the group consisting of an unsubstituted C 1-6 alkyl, a substituted or unsubstituted aryl, a substituted or unsubstituted heteroaryl, a substituted or unsubstituted heterocycloalkyl, a substituted or unsubstituted aryl(C 1-6 alkyl), a substituted or unsubstituted heteroaryl(C 1-6 alkyl) and a substituted or unsubstituted heterocycloalkyl(C 1-6 alkyl);
X a is hydrogen, an unsubstituted C 1-6 alkyl, a halogen substituted C 1-6 alkyl, a hydroxy substituted C 1-6 alkyl or an unsubstituted C 1-6 alkoxy;
wherein alkyl is fully saturated; and
wherein the substituent is selected from the following moieties: -OH, -NH 2 , -SH, -CN, -CF 3 , -NO 2 , oxo, halogen, unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, and unsubstituted heteroaryl.
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Inventors:
Karst Wye
Beadle, James Earl
Barrier Eve, Najuda
Beadle, James Earl
Barrier Eve, Najuda
Application Number:
JP2016502307A
Publication Date:
January 30, 2019
Filing Date:
March 14, 2014
Export Citation:
Assignee:
The Regents of The University of California
International Classes:
C07F9/6561; A61K31/675; A61P31/14; A61P31/18; A61P31/20; A61P31/22; A61P35/00; A61P43/00; C07F9/6512
Domestic Patent References:
| JP4230694A | ||||
| JP2008538771A | ||||
| JP2004500352A | ||||
| JP2009538829A | ||||
| JP2013501056A |
Foreign References:
| WO2006076015A1 | ||||
| CN101089004A |
Other References:
Antiviral Research,2006年,72,pp.10-19
Nucleosides & Nucleotides,1995年,14(3-5),pp.767-770
Nucleosides & Nucleotides,1995年,14(3-5),pp.767-770
Attorney, Agent or Firm:
Kawaguchi International Patent Office