Title:
葉酸受容体１の検出のための診断分析およびキット
Document Type and Number:
Japanese Patent JP6480558
Kind Code:
B2
Abstract:
The invention generally relates to antibodies that bind to human folate receptor 1 and diagnostic assays for folate receptor 1 -based therapies. Methods of using the antibodies to monitor therapy are further provided. The present invention provides methods for detection of FOLRI in a sample and can be used, for example, to stratify patients. Thus, in one embodiment, the invention provides a method of treating a patient having a folate receptor 1 -mediated disease comprising: (a) measuring the shed folate receptor 1 (FOLRI) expression level or FOLRI on a circuiting tumor cell (CTC) in a sample taken from a patient.
Inventors:
Nathan E. Tester
Christina N. Carrigan
Olga Abu
Daniel Tavares
Beni Bee. Wolf
Christina N. Carrigan
Olga Abu
Daniel Tavares
Beni Bee. Wolf
Application Number:
JP2017247587A
Publication Date:
March 13, 2019
Filing Date:
December 25, 2017
Export Citation:
Assignee:
Immunogen, Inc.
International Classes:
C12N15/13; C07K14/705; C07K16/28; C07K16/46; C07K17/00; C07K19/00; C12N5/10; C12P21/08; C12Q1/28; G01N33/483; G01N33/53; G01N33/543; G01N33/574
Foreign References:
| WO2011106528A1 | ||||
| WO2012061759A1 | ||||
| WO2011016238A1 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto