Title:
置換二環式ジヒドロピリミジノン及び好中球エラスターゼ活性の阻害薬としてのそれらの使用
Document Type and Number:
Japanese Patent JP6501864
Kind Code:
B2
Abstract:
This invention relates to substituted bicyclic dihydropyrimidinones of formula 1and their use as inhibitors of neutrophil elastase activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of pulmonary, gastrointestinal and genitourinary diseases, inflammatory diseases of the skin and the eye and other autoimmune and allergic disorders, allograft rejection, and oncological diseases.
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Inventors:
Gnum Christian
Andels Skewitz Ralph
Heche Holger
Morschhauser Gert
Ost torsten
Peters Stephan
Reese Uwe Jörg
Andels Skewitz Ralph
Heche Holger
Morschhauser Gert
Ost torsten
Peters Stephan
Reese Uwe Jörg
Application Number:
JP2017505452A
Publication Date:
April 17, 2019
Filing Date:
July 30, 2015
Export Citation:
Assignee:
Boehringer Ingelheim International GmbH
International Classes:
C07D471/04; A61K31/519; A61K31/5377; A61K31/541; A61K45/00; A61P1/04; A61P1/16; A61P3/04; A61P3/06; A61P3/10; A61P7/00; A61P9/00; A61P9/12; A61P11/00; A61P11/06; A61P11/08; A61P11/16; A61P13/12; A61P19/02; A61P25/28; A61P29/00; A61P31/00; A61P35/00; A61P37/06; A61P37/08; A61P43/00; C07D519/00
Domestic Patent References:
| JP2012516316A | ||||
| JP2009535389A | ||||
| JP2007523931A |
Foreign References:
| WO2014135414A1 | ||||
| WO2014030743A1 |
Other References:
The Journal of Organic Chemistry,2014年,Vol.79,pp.2281-2288
Attorney, Agent or Firm:
Takaki Nishijima
Disciple Maru Ken
Shinichiro Tanaka
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Satsuki Ichikawa
Hironobu Hattori
Akizawa
Disciple Maru Ken
Shinichiro Tanaka
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Satsuki Ichikawa
Hironobu Hattori
Akizawa