ＷＮＴ経路のモジュレーターとしてのマレイミド誘導体 - AGENCY FOR SCIENCE,TECHNOLOGY AND RESEARCH

Title:

ＷＮＴ経路のモジュレーターとしてのマレイミド誘導体

Document Type and Number:

Japanese Patent JP6511450

Kind Code:

B2

Abstract:

The present invention relates to compounds of formula (I), combinations and uses thereof for disease therapy, or a pharmaceutically acceptable salt, solvate or polymorph therof, including all tautomers and stereoisomers thereof wherein R1represents optionally substituted alkyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkoxy); optionally substituted carbocyclyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy and halo); or -alkylaryl; R2 represents H; or alkyl; R3 represents H; or alkyl; U, V and W represent -(CH2)-; or U and V together represent -CH=CH- and W represents C=O; Y represents aryl; heteroaryl; optionally substituted carbocyclyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkyl, C1-6alkoxy, C1- 6haloalkyl, C1-6haloalkoxy and halo); or optionally substituted heterocyclyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkyl, C1-6 alkoxy, -C(O)OC1-6alkyl, -C(O)C1-6alkyl and-C(O)NHC1-6alkyl); and Z represents aryl; heteroaryl; optionally substituted carbocyclyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkyl, C1-6alkoxy, C1- 6haloalkyl, C1-6haloalkoxy and halo); or optionally substituted heterocyclyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkyl, C1-6. alkoxy, -C(O)OC1-6alkyl, -C(O)C1-6alkyl and -C(O)NHC1-6alkyl).

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Inventors:

Genepher Alam
Anus Poulsen
Sue Ye Ho
Way Lin Wan
Atithaya Mani Jeyaraji Druiswami

Application Number:

JP2016540530A

Publication Date:

May 15, 2019

Filing Date:

December 17, 2014

Export Citation:

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Assignee:

AGENCY FOR SCIENCE,TECHNOLOGY AND RESEARCH

International Classes:

C07D471/04; A61K31/437; A61K31/444; A61K31/497; A61K31/501; A61K31/506

Foreign References:

WO2015187094A1
WO2010075282A1
WO2013151708A1
WO2012136492A1

Attorney, Agent or Firm:

Mitsuo Tanaka
Hiroshi Yamazaki
Tsuyoshi Sato

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