Title:
最小毒性プロドラッグ
Document Type and Number:
Japanese Patent JP6523965
Kind Code:
B2
Abstract:
The present invention relates to the field of oligopeptide prodrugs that are intended for the treatment of cancer. The selectivity of these prodrugs requires the presence of an (oligo)peptidic moiety and/or a protective capping group to ensure the prodrug stability in blood. It further in particular relates to the exemplary oligopeptidic moiety ALGP and to prodrugs comprising it. In particular it also relates to the capping group phosphonoacetyl and to prodrugs comprising this capping group.
Inventors:
Andre Torue
Application Number:
JP2015550080A
Publication Date:
June 05, 2019
Filing Date:
December 27, 2013
Export Citation:
Assignee:
COBIORES NV
International Classes:
C12Q1/02; C12Q1/37; C40B30/06; G01N33/15; G01N33/50
Domestic Patent References:
| JP2003518000A | ||||
| JP2008545661A |
Other References:
FERNANDEZ, A.M., et al.,J. MED. CHEM.,2001年,Vol.44,pp.3750-3753
HU, Z., et al.,BIOORG. MED. CHEM. LETT.,2010年,Vol.20,pp.853-856
HEINIS, C., et al.,BIOCHEMISTRY,2004年,Vol.43,pp.6293-6303
EDOSADA, C.Y., et al.,FEBS LETT.,2006年,Vol.580,pp.1581-1586
LAI, K.S., et al.,BIOCONJUGATE CHEM.,2007年,Vol.18,pp.1246-1250
SHIOSE, Y., et al.,BIOCONJUGATE CHEM.,2009年,Vol.20,pp.60-70
HU, Z., et al.,BIOORG. MED. CHEM. LETT.,2010年,Vol.20,pp.853-856
HEINIS, C., et al.,BIOCHEMISTRY,2004年,Vol.43,pp.6293-6303
EDOSADA, C.Y., et al.,FEBS LETT.,2006年,Vol.580,pp.1581-1586
LAI, K.S., et al.,BIOCONJUGATE CHEM.,2007年,Vol.18,pp.1246-1250
SHIOSE, Y., et al.,BIOCONJUGATE CHEM.,2009年,Vol.20,pp.60-70
Attorney, Agent or Firm:
Norihito Yamao
Yasushi Ochiai
Yasushi Ochiai