Title:
ロチゴチンを含む経皮送達システム
Document Type and Number:
Japanese Patent JP6573913
Kind Code:
B2
Abstract:
The present invention relates to transdermal therapeutic systems for the transdermal administration of rotigotine containing a therapeutically effective amount of rotigotine base in a self-adhesive layer structure that includes a backing layer and a rotigotine-containing biphasic layer. The biphasic layer has an outer phase formed from a polymer or a polymer mixture along with an inner phase that includes rotigotine base and a polymer mixture including polyvinylpyrrolidone having a K-Value of at least 80 and at least one further hydrophilic polymer selected from the polymer groups: copolymers of vinyl caprolactam, vinylacetate and ethylene glycol, copolymers of vinylpyrrolidone and vinylacetate, copolymers of ethylene and vinylacetate, polyethylene glycols, polypropylene glycols, acrylic polymers, and modified celluloses. The inner phase forms dispersed deposits in the outer phase. The inventive transdermal therapeutic systems optionally include a skin contact layer.
Inventors:
Marco Amgenbroich
Elke Klein
Haike Cruz
Elke Klein
Haike Cruz
Application Number:
JP2016568496A
Publication Date:
September 11, 2019
Filing Date:
May 20, 2015
Export Citation:
Assignee:
Ertes Roman Therapy-The Steme Age
International Classes:
A61K9/70; A61K31/381; A61K47/10; A61K47/32; A61K47/34; A61K47/38; A61P21/00; A61P25/16; A61P25/22; A61P25/24; A61P25/28
Domestic Patent References:
| JP2013510805A | ||||
| JP2005535687A | ||||
| JP2004528359A | ||||
| JP2004525164A | ||||
| JP2011500647A | ||||
| JP2011526592A | ||||
| JP2010532390A |
Foreign References:
| WO2012084969A1 | ||||
| DE102012013421A1 |
Attorney, Agent or Firm:
Junji Yuda
Noriyuki Takebayashi
Noriyuki Takebayashi