Title:
薬物送達タンパク質の輸送向上変異体の単離
Document Type and Number:
Japanese Patent JP6618360
Kind Code:
B2
Abstract:
The invention relates to methods for isolating traffic-enhancing mutants of drug delivery proteins. In one embodiment, the invention provides a carrier for delivering a therapeutic agent to an organelle, comprising a polypeptide encoded by a mutant penton base gene. In another embodiment, the invention provides a method of enhancing trafficking to a cell by administering a composition comprising a penton base (PB) protein with one or more mutations that enhance cellular entry.
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Inventors:
Medina-Cowwell Rake.
Application Number:
JP2015525636A
Publication Date:
December 11, 2019
Filing Date:
August 02, 2013
Export Citation:
Assignee:
Cedars-Sinai Medical Center
International Classes:
A61K47/42; A61P35/00
Domestic Patent References:
| JP10505242A | ||||
| JP2001521376A | ||||
| JP11501219A |
Foreign References:
| WO2009009441A1 | ||||
| US20120004181 | ||||
| WO2002024934A1 | ||||
| EP1266963A1 |
Attorney, Agent or Firm:
Masayuki Masabayashi
Hayashi Ichiyoshi
Tetsuo Shiba
Iwaike Mitsuru
Hayashi Ichiyoshi
Tetsuo Shiba
Iwaike Mitsuru