Title:
三重特異性結合分子及びその使用方法
Document Type and Number:
Japanese Patent JP6647222
Kind Code:
B2
Abstract:
The present invention relates to Tri-Specific Binding Molecules, which are multi-chain polypeptide molecules that possess three Binding Domains and are thus capable of mediating coordinated binding to three epitopes. The Binding Domains may be selected such that the Tri-Specific Binding Molecules are capable of binding to any three different epitopes. Such epitopes may be epitopes of the same antigen or epitopes of two or three different antigens. In a preferred embodiment, one of such epitopes will be capable of binding to CD3, the second of such epitopes will be capable of binding to CD8, and the third of such epitopes will be capable of binding to an epitope of a Disease-Associated Antigen. The invention also provides a novel ROR1-binding antibody, as well as derivatives thereof and uses for such compositions.
Inventors:
Johnson Leslie S.
Juan Lin
Chichiri Grunad Lady
Shah Carpana
Lamb Char Inn Khao
Burke Stephen James
Lily kin
Moore Paul A.
Bombini Ezio
Baller Baswati
Juan Lin
Chichiri Grunad Lady
Shah Carpana
Lamb Char Inn Khao
Burke Stephen James
Lily kin
Moore Paul A.
Bombini Ezio
Baller Baswati
Application Number:
JP2016570005A
Publication Date:
February 14, 2020
Filing Date:
May 29, 2015
Export Citation:
Assignee:
Macrogenics, Incorporated
International Classes:
C07K19/00; A61K39/395; A61P35/00; C07K16/28; C07K16/32; C07K16/46
Domestic Patent References:
| JP2012528092A | ||||
| JP2013540696A |
Attorney, Agent or Firm:
Shiro Isoda