Title:
蛋白質吸着抑制剤および蛋白質吸着抑制の方法
Document Type and Number:
Japanese Patent JP6803371
Kind Code:
B2
Abstract:
The present invention addresses the problem of providing a protein adsorption inhibitor which can inhibit the non-specific adsorption of a protein, e.g., an antibody and an enzyme, onto a solid surface of a base material, e.g., an immune reaction vessel and a measurement tool, at a high level and which has improved wet-scrub resistance. The problem can be solved by a protein adsorption inhibitor which contains a water-soluble acrylic polymer (P) as an active ingredient, wherein the water-soluble acrylic polymer (P) contains a repeating constituent unit [A] represented by formula (1), has a number average molecular weight of 5,000 to 250,000 and has an LCST of 25 to 45ºC. [R1 represents a hydrogen atom or a methyl group; R2 represents a methyl group or an ethyl group; and n means the average number of moles of an oxyalkylene group added and represents 2 to 3.]
Inventors:
Masaru Tanaka
Satoshi Yamada
Nobuyuki Sakamoto
Satoshi Yamada
Nobuyuki Sakamoto
Application Number:
JP2018504575A
Publication Date:
December 23, 2020
Filing Date:
March 09, 2017
Export Citation:
Assignee:
Yamagata University
NOF CORPORATION
NOF CORPORATION
International Classes:
G01N33/531; C08F20/28; C08J7/056
Domestic Patent References:
| JP2011225769A | ||||
| JP2013057058A | ||||
| JP2014102194A | ||||
| JP2013148484A | ||||
| JP10153599A | ||||
| JP3443891B2 |
Foreign References:
| WO2008146631A1 | ||||
| WO2013024815A2 |
Other References:
KITANO, Hiromi et al.,Temperature-responsive polymer-brush constructed on a grass substrate by atom transfer radical polymerization,Journal of Colloid and Interface Science,2010年,Vol. 345,p. 325-331
YOON, Jeong Ae et al.,Comparison of the Thermoresponsive Deswelling Kinetics of Poly(2-(2-methoxyethoxy)ethyl methacrylate) Hydrogels Prepared by ATRP and FRP,Macromolecules,American Chemical Society,2010年,Vol. 43,p. 4791-4797
YOON, Jeong Ae et al.,Comparison of the Thermoresponsive Deswelling Kinetics of Poly(2-(2-methoxyethoxy)ethyl methacrylate) Hydrogels Prepared by ATRP and FRP,Macromolecules,American Chemical Society,2010年,Vol. 43,p. 4791-4797
Attorney, Agent or Firm:
Hiroshi Kobayashi
Taro Ushio
Yasuhito Suzuki
Taro Ushio
Yasuhito Suzuki