Title:
セロトニン受容体を標的にする化合物および方法
Document Type and Number:
Japanese Patent JP6817073
Kind Code:
B2
Abstract:
This invention relates to, in part, compositions and methods that are useful for, inter alia, the treatment of various diseases, including those linked to binding at a serotonin receptor. The compositions include chiral tetrahydronaphthalen-2-amine derivatives. Accordingly, the present invention provides for compositions and methods that agonize or antagonize one or more serotonin receptors and which find Use in the treatment of various neuropsychiatric diseases or disorders including, without limitation, autism spectrum disorder (ASD) or associated symptoms.
Inventors:
Booth, Raymond, Gee.
Application Number:
JP2016568912A
Publication Date:
January 20, 2021
Filing Date:
May 19, 2015
Export Citation:
Assignee:
Northeastern University
International Classes:
A61K31/135; A61K31/472; A61P3/04; A61P25/00; A61P25/14; A61P25/18; A61P25/22; A61P43/00; C07C211/42; C07C217/56; C07D217/14; C07D307/52
Domestic Patent References:
| JP2003012648A | ||||
| JP10513479A | ||||
| JP2010522223A | ||||
| JP2010517952A |
Other References:
Journal of Medicinal Chemistry,2004年,Vol. 47, No. 16,pp. 3927-3930
Journal of Medicinal Chemistry,2003年,Vol.46, No.25,p.5365-5374
NEW薬理学,株式会社南江堂,2012年,第6版第3刷,第121-131頁
J. Chem. Inf. Model.,2005年,Vol. 45, No. 4,pp. 1075-1081
Neuropharmacology,2005年,Vol.48,pp.492-502
Journal of Medicinal Chemistry,2003年,Vol.46, No.25,p.5365-5374
NEW薬理学,株式会社南江堂,2012年,第6版第3刷,第121-131頁
J. Chem. Inf. Model.,2005年,Vol. 45, No. 4,pp. 1075-1081
Neuropharmacology,2005年,Vol.48,pp.492-502
Attorney, Agent or Firm:
Kiyoji Kuzuwa