Title:
合成ペプチド化合物及び使用方法
Document Type and Number:
Japanese Patent JP6820917
Kind Code:
B2
Abstract:
The present invention provides synthetic peptide compounds and uses thereof for therapy and diagnostics of complement-mediated diseases, such as inflammatory diseases, autoimmune diseases, and microbial and bacterial infections; and non-complement-mediated diseases, such cystic fibrosis and various acute diseases. The invention is directed to modifications of a synthetic peptide of 15 amino acids from the Polar Assortant (PA) peptide, which is a scrambled peptide derived from human Astrovirus protein. In some embodiments, the invention is directed to peptide compounds that are peptide mimetics, peptide analogs and/or synthetic derivatives of PA (e.g., sarcosine derivatives) having, for example, internal peptide substitutions, and modifications, including PEGylation at the N-terminus and C-terminus. The invention further provides methods of selecting at least one synthetic peptide for treating various conditions.
Inventors:
Krishna Neal Kay.
Kunion Kenji
Kunion Kenji
Application Number:
JP2018519267A
Publication Date:
January 27, 2021
Filing Date:
June 24, 2016
Export Citation:
Assignee:
REALTA Holdings Limited Liability Company
International Classes:
A61K38/10; A61K47/60; A61P1/14; A61P7/00; A61P7/06; A61P11/00; A61P13/12; A61P25/00; A61P31/04; A61P31/12; A61P37/00; A61P43/00; C07K7/08
Domestic Patent References:
| JP2013533273A |
Other References:
Mol. Immunol., (2013), 53, [1-2], p.132-139
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto