Title:
骨芽細胞の分化促進剤および骨形成促進剤
Document Type and Number:
Japanese Patent JP6860877
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To provide a tripeptide represented by X-Hyp-Gly, (where, X is an amino acid residue except Gly, Hyp, and Glu), and to provide osteoblast differentiation-promoting agents and osteogenesis promoting agents which contain the tripeptide.SOLUTION: Provided is a tripeptide represented by X-Hyp-Gly (where, X is an amino acid residue except Gly, Hyp, and Glu) or a pharmaceutically acceptable salt thereof. The tripeptide (salt) can be used as an osteoblast differentiation-promoting agent and osteogenesis promoting agent due to promoting osteoblast differentiation and promoting osteogenesis.SELECTED DRAWING: None
Inventors:
Yuuki Taga
Kusunoki Masa
Kiyoko Goto
Shunji Hattori
Noriko Funato
Kusunoki Masa
Kiyoko Goto
Shunji Hattori
Noriko Funato
Application Number:
JP2016193980A
Publication Date:
April 21, 2021
Filing Date:
September 30, 2016
Export Citation:
Assignee:
Nippi Corporation
Tokyo Medical And Dental University, Medical Hospital
Tokyo Medical And Dental University, Medical Hospital
International Classes:
A61K38/39; A61K38/06; A61P19/08
Foreign References:
| WO2014017474A1 |
Other References:
Tsuruoka N et al.,Promotion by collagen tripeptide of type I collagen gene expression in human osteoblastic cells and fracture healing of rat femur,Bioscience, Biotechnology, and Biochemistry,2007年,Vol.71, No.11,p.2680-2687,doi:10.1271/bbb.70287
Kimira Y et al.,Collagen-derived dipeptide prolyl-hydroxyproline promotes differentiation of MC3T3-E1 osteoblastic cells,Biochemical and Biophysical Research Communications,2014年,Vol.453, No.3,p.498-501,doi:10.1016/j.bbrc.2014.09.121
Liu J et al.,Bovine collagen peptides compounds promote the proliferation and differentiation of MC3T3-E1 pre-osteoblasts,PLoS One,2014年,Vol.9, No.6,e99920,doi:10.1371/journal.pone.0099920
Kimira Y et al.,Collagen-derived dipeptide prolyl-hydroxyproline promotes differentiation of MC3T3-E1 osteoblastic cells,Biochemical and Biophysical Research Communications,2014年,Vol.453, No.3,p.498-501,doi:10.1016/j.bbrc.2014.09.121
Liu J et al.,Bovine collagen peptides compounds promote the proliferation and differentiation of MC3T3-E1 pre-osteoblasts,PLoS One,2014年,Vol.9, No.6,e99920,doi:10.1371/journal.pone.0099920
Attorney, Agent or Firm:
Kimura Mitsuru
Etsuko Saito
Etsuko Saito