Title:
ＴＥＡＤ相互作用を妨害するためのペプチド組成物およびその使用方法
Document Type and Number:
Japanese Patent JP7191025
Kind Code:
B2
Abstract:
Described herein are peptides and variants and mutants thereof capable of interacting with TEAD, disrupting the HIPPO pathway, or modulating the activity or function of TEAD interactions in a cell. Pharmaceutical compositions and uses of peptides, as well as methods of designing and manufacturing such peptides, to treat cancer, tumor, or any other disease/condition associated with a dysregulated HIPPO pathway or uncontrolled cell growth are also described herein.
Inventors:
Olson, James M.
Crook, Zaccary
Bradley, Philip H.
Crook, Zaccary
Bradley, Philip H.
Application Number:
JP2019534346A
Publication Date:
December 16, 2022
Filing Date:
January 18, 2018
Export Citation:
Assignee:
Fred Hutchinson Cancer Center
International Classes:
C07K14/00; A61K47/64; A61K49/14; A61P3/10; A61P35/00
Foreign References:
| WO2016196560A1 |
Other References:
Gene and Development,2010年,Vol.24 ,p235-240,https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811825/参照
Cancer Research,2016年07月,Vol. 76, No. 14,Supplement. Abstract Number: 2971,https://cancerres.aacrjournals.org/content/76/14_Supplement/2228参照
Cancer Research,2016年07月,Vol. 76, No. 14,Supplement. Abstract Number: 2971,https://cancerres.aacrjournals.org/content/76/14_Supplement/2228参照
Attorney, Agent or Firm:
Shusaku Yamamoto
Morishita Natsuki
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Morishita Natsuki
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto