Title:
合成新規ピロロイミノキノンアルカロイド及び使用の方法
Document Type and Number:
Japanese Patent JP7389809
Kind Code:
B2
Abstract:
Aleutianamine represents the first in a new class of pyrroloiminoquinone alkaloids possessing a highly strained multi-bridged ring system, discovered from Latrunculia (Latrunculia) austini Samaai, Kelly & Gibbons, 2006 (class Demospongiae, order Poecilosclerida, family Latrunculiidae) recovered during a NOAA deep-water exploration of the Aleutian Islands. Aleutianamine exhibited potent and selective cytotoxicity toward solid tumor cell lines including pancreatic cancer (PANC-1) with an IC50 of 25 nM and colon cancer (H116) with IC50 of 1 μM.
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Inventors:
Mark T. HAMANN
Application Number:
JP2021540307A
Publication Date:
November 30, 2023
Filing Date:
January 09, 2020
Export Citation:
Assignee:
Mark T. HAMANN
International Classes:
A61K31/55; A61P35/00; C07D513/22
Domestic Patent References:
| JP1500993A | ||||
| JP63310892A | ||||
| JP1199974A | ||||
| JP1258679A |
Foreign References:
| WO2008103483A2 | ||||
| WO2018170019A1 |
Other References:
Yike Zou et al.,Computationally Assisted Discovery and Assignment of a Highly Strained and PANC-1 Selective Alkaloid from Alaska's Deep Ocean,Journal of the American Chemical Society,2019年02月13日,Vol.141,p.4338-4344,https://doi.org/10.1021/jacs.8b11403
Attorney, Agent or Firm:
Koji Murai
Takayuki Ishikawa
Takayuki Ishikawa