Title:
【発明の名称】免疫抑制の予知および診断のための胎盤イソフェリチン
Document Type and Number:
Japanese Patent JPH03504272
Kind Code:
A
Abstract:
Methods for the diagnosis and prognosis of immunosuppressive conditions are disclosed, involving the detection of a particular isoform of ferritin, placental ferritin (PLF), in patient samples such as sera or on peripheral blood lymphocytes. PLF is elevated in immunosuppressed patients at early stages of disease; by contrast, adult isoferritins are elevated at late stages of immunodeficiency. Depending upon the nature of the disease associated with the immunodeficiency, the elevated levels of PLF detected at early stages may remain elevated or diminish as disease progresses. Examples are described in which elevated levels of PLF were detected at very early stages of HIV-infection. The elevated levels diminished as disease progressed from ARC to AIDS. By contrast, adult isoforms of ferritin became elevated at late stages of disease.
Inventors:
Moroz, Chaya
Mizurock, Es, Leslie
Mizurock, Es, Leslie
Application Number:
JP50399189A
Publication Date:
September 19, 1991
Filing Date:
March 06, 1989
Export Citation:
Assignee:
Moroz, Chaya
Mizurock, Es, Leslie
Mizurock, Es, Leslie
International Classes:
C07K16/18; C12N5/10; C12N15/02; C12P21/08; G01N33/53; G01N33/569; G01N33/68; C12R1/91; (IPC1-7): C12N5/20; C12N15/06; C12P21/08; G01N33/53; G01N33/569
Domestic Patent References:
| JPS5719614A | 1982-02-01 |
Attorney, Agent or Firm:
Yusuke Hiraki