Title:
【発明の名称】アミノ酸誘導体と、その製造方法と、その治療への応用
Document Type and Number:
Japanese Patent JPH04501868
Kind Code:
A
Abstract:
Amino acid drivatives, enkephalinase and ACE inhibitors, of the formula (Ia) and (Ib), wherein R1 represents a biphenyl group or one of the groups (a), wherein Z, Y and n have the meanings (b) or (c), wherein R'1, represents a hydrogen atom, a lower alkyl group; a phenyl group; a lower phenylalkylene group. R2 represents a hydrogen atom; a lower alkyl group; a lower hydroxyalkylene group; a lower phenylalkylene group; a lower hydroxyphenylalkylene group; a lower aminoalkylene group; a lower guanidinoalkylene group; a lower mercaptoalkylene group; a lower thioalkylene lower alkyl group; a lower imidazolylkylene group; a lower indolylalkylene group; a lower carbamylalkylene group; a lower carboxyalkylene group or one of the groupings (d), where Z, Y and n have the meanings (e), X indicates a grouping responsible for chelating the zinc atom of enzymes, enkephalinase and ACE, and may be selected from the group which comprises a mercaptomethyl; hydroxamic acid; an N-carboxyalkyl of the formula (f), wherein R3 represents a benzyl lower alkyl radical, or a benzyl lower alkoxy radical; phosphorus-containing derivatives of the formula (g) or (h).
Inventors:
Prokvain, Jean-Christophe
Dunvi, Duni
Monterey, Thierry
Grecie, Helene
Duhamel, russet
Duhamel, Pierre
Gro, Claude
Schwarz, Jean-Charles
Lecomte, Jeanne-Marie
Dunvi, Duni
Monterey, Thierry
Grecie, Helene
Duhamel, russet
Duhamel, Pierre
Gro, Claude
Schwarz, Jean-Charles
Lecomte, Jeanne-Marie
Application Number:
JP51328990A
Publication Date:
April 02, 1992
Filing Date:
September 14, 1990
Export Citation:
Assignee:
Societe Civil Bioproge
International Classes:
A61K31/195; A61K31/335; A61K31/357; A61K31/36; A61K31/403; A61K31/404; A61K31/405; A61K31/66; A61K31/685; A61K38/00; A61K38/55; A61P7/10; A61P9/12; A61P43/00; C07C323/60; C07C327/28; C07D209/20; C07D307/78; C07D307/79; C12N9/99; C07D317/60; C07D319/18; C07D405/12; C07F9/24; C07F9/38; C07F9/655; C07K1/113; C07K5/06; C07K14/81; (IPC1-7): A61K31/195; A61K31/335; A61K31/36; A61K31/405; A61K31/66; A61K31/685; A61K37/02; A61K37/64; C07C323/60; C07C327/28; C07D209/20; C07D307/78; C07D317/60; C07D319/18; C07F9/24; C07F9/38; C07F9/655; C07K5/06; C12N9/99
Attorney, Agent or Firm:
Takashi Koshiba