Title:
【発明の名称】疾患関連マーカーとしてのT細胞レセプター可変トランスクリプト
Document Type and Number:
Japanese Patent JPH05506995
Kind Code:
A
Abstract:
Methods are provided for determining relations between autoimmune degenerative diseases and specific variable regions of T-cell receptors as associated with the host HLA or T-cells associated with combatting neoproliferative diseases. By identifying the particular T-cell receptors which cause or are the disease in mammals, various prophylactic and therapeutic techniques may be employed for inhibiting the attack of the T-cell receptors on the native protein or tissue enhancing the defense. In addition, individuals may be diagnosed as to their propensity for a particular autoimmune disease or the occurrence of such a disease.
Inventors:
Steinman Lawrence
Oxenburg George
Bernard Claude
Oxenburg George
Bernard Claude
Application Number:
JP50939091A
Publication Date:
October 14, 1993
Filing Date:
May 01, 1991
Export Citation:
Assignee:
The Board of Trustees of the Leland Stanford Junior University
International Classes:
A61K35/12; A61K35/14; A61K35/17; C12N5/08; C12Q1/68; G01N33/53; G01N33/564; G01N33/569; G01N33/574; (IPC1-7): C12Q1/68; C12Q1/68; G01N33/53; G01N33/564
Attorney, Agent or Firm:
Minoru Nakamura (7 outside)