Title:
【発明の名称】新規な抗ウィルス性テトラヒドロイミダゾ[1,4]ベンゾジアゼピン―2―(チ)オン
Document Type and Number:
Japanese Patent JPH05508632
Kind Code:
A
Abstract:
Novel tetrahydroimidazo[1,4]benzodiazepin-2-(thio)ones of formula (I), the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein X is O or S; R<1> is a radical of formula (a-1); (a-2); (a-3) or (a-4); R<2> is hydrogen or C1-6alkyl; R3 is hydrogen or C1-6alkyl; R<4> and R<5> each independently are hydrogen, C1-6alkyl, halo, cyano, nitro, trifluoromethyl, hydroxy, C1-6alkyloxy, amino, mono- or di(C1-6alkyl)amino, C1-6alkylcarbonylamino or arylcarbonylamino, possessing antiviral activity. Compositions containing these compounds as active ingredient and methods of treating subjects suffering from viral infections by administering said compounds.
Inventors:
Kukula, Michael Joseph
Breslin, Henry Joseph
Remekaz, Alphonse Hermann Margareta
Juan Gelder, Josephus Ludovics Hubertous
Paul Jensen, Paul Adrien Jiang
Breslin, Henry Joseph
Remekaz, Alphonse Hermann Margareta
Juan Gelder, Josephus Ludovics Hubertous
Paul Jensen, Paul Adrien Jiang
Application Number:
JP51109491A
Publication Date:
December 02, 1993
Filing Date:
June 28, 1991
Export Citation:
Assignee:
JANSSEN PHARMACEUTICA NAAMLOZE VENNOOTSCHAP
International Classes:
A61P31/12; A61P31/18; A61K31/55; C07D235/26; C07D235/28; C07D243/14; C07D487/04; C07D487/06; (IPC1-7): C07D487/06; A61K31/55
Attorney, Agent or Firm:
Heikichi Odashima