Japanese Patent JPH0564949

B2

Novel fluorinated 1-( alpha -phenylalkyl)-1H-1,2,3-triazole compounds of the formula: in which Ph denotes a phenyl radical which is substituted in the o-position by fluorine and optionally additionally by at least one further halogen atom, alk represents lower alkylidene, R1 denotes hydrogen, lower alkyl or an unsubstituted or lower alkanoyl- or lower alkyl-substituted carbamyl group and R2 represents an unsubstituted or lower alkanoyl or lower alkyl-substituted carbamyl group, have anticonvulsive properties and are utilisable as medicaments. They are prepared by reacting a compound of the formula in which Y4 denotes esterified carboxyl and Y5 represents hydrogen, lower alkyl or, alternatively, esterified carboxyl, with an excess of ammonia or a di(lower alkylamine), and if desired lower-alkanoylating R2 and optionally R1 in a compound obtainable according to the process in which R2 and optionally R1 denote unsubstituted carbamyl.

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REENE MAIAA

JP8838486A

September 16, 1993

April 18, 1986

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CIBA GEIGY

A61K31/41; A61P25/08; C07C33/46; C07D249/04; (IPC1-7): C07D249/04; A61K31/41

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