Title:
【発明の名称】抗体が仲介する共同因子作動型反応
Document Type and Number:
Japanese Patent JPH06500098
Kind Code:
A
Abstract:
Chemical reactions capable of being rate-enhanced by auxiliary species which interact with the reactants but do not become chemically bound to them in the formation of the final product are performed in the presence of antibodies which promote the reactions. The antibodies contain regions within their antigen binding sites which recognize the auxiliary species in a conformation which promotes the reaction. The antigen binding site frequently recognizes a particular transition state complex or other high energy complex along the reaction coordinate, thereby promoting the progress of the reaction along the desired route as opposed to other less favorable routes. Various classes of reaction together with appropriate antigen binding site specificities tailored for each are disclosed.
Inventors:
Schultz Peter G.
Application Number:
JP51405191A
Publication Date:
January 06, 1994
Filing Date:
June 27, 1991
Export Citation:
Assignee:
The Regents of The University of California
International Classes:
C07K1/107; C07K16/00; C12N9/00; C12N15/02; C12P1/00; C12P7/22; C12P13/00; C12P17/00; C12P17/16; C07K14/00; C12P21/08; C12R1/91; (IPC1-7): C07K15/12; C07K3/08; C12N9/00; C12P1/00; C12P21/08
Attorney, Agent or Firm:
Shoichi Hase (2 outside)