Title:
【発明の名称】ヒト免疫不全症候ヴィールスに対する痘苗(ワクチン)および治療方法
Document Type and Number:
Japanese Patent JPH06501851
Kind Code:
A
Abstract:
An Acquired Immunodeficiency Syndrome (AIDS) vaccine containing the Human Immunodeficiency Virus, Type-1 (HIV-1) envelope proteins is produced from cloned HIV-1 envelope genes in a baculovirus-insect cell vector system. The recombinant HIV-1 proteins are purified, assembled into particles and then adsorbed on an aluminum phosphate adjuvant. The resulting adsorbed recombinant HIV-1 virus envelope protein formulation (AIDS vaccine) is highly immunogenic in animals and elicits antibodies which bind to the HIV-1 virus envelope and neutralize the infectivity of the virus in in vitro tests. The above AIDS vaccine induces new humoral and cellular immune responses in HIV-infected patients and is useful as a form of vaccine therapy to delay or prevent the destruction of the immune system.
Inventors:
Gale Jugen Smith
Franklin Volvowitz
Franklin Volvowitz
Application Number:
JP50104093A
Publication Date:
March 03, 1994
Filing Date:
June 10, 1992
Export Citation:
Assignee:
Micro Genesis Incorporated
International Classes:
A61K39/21; A61P31/12; C07K14/00; C07K14/155; C07K14/705; C12N5/00; C12N15/09; C12N15/49; C12P21/02; C12R1/91; (IPC1-7): C12N15/49; A61K39/21; C07K13/00; C12N5/10; C12P21/02
Attorney, Agent or Firm:
Kenji Ishiguro