Title:
【発明の名称】新規免疫抑制化合物
Document Type and Number:
Japanese Patent JPH06508141
Kind Code:
A
Abstract:
This invention relates to anovel class of immuno-suppressive compounds having an affinity for the FK-506 binding protein (FKBP). Once bound to this protein, the immunosuppressive compounds inhibit the prolyl peptidyl cis-trans isomerase (rotamase) activity of the FKBP and inhibit T cell activation. As such, the compounds of this invention can be used as immunosuppressive drugs to prevent or significantly reduce graft rejection in bone marrow and organ transplantations and for use in the treatment of a wide variety of autoimmune diseases in humans and other mammals.
Inventors:
Duffy, John Pee.
Application Number:
JP50049793A
Publication Date:
September 14, 1994
Filing Date:
May 26, 1992
Export Citation:
Assignee:
VERTEX PHARMACEUTICALS INCORPORATED
International Classes:
A61K31/18; A61K31/40; A61K31/4427; A61K31/4433; A61K31/445; A61P37/06; C07C311/02; C07D207/48; C07D211/60; C07D211/96; C07D401/12; C07D409/12; (IPC1-7): C07D207/48; A61K31/18; A61K31/40; A61K31/445; C07C311/02; C07D211/60; C07D401/12; C07D409/12
Attorney, Agent or Firm:
Shusaku Yamamoto