Title:
【発明の名称】6位に環状基を含む置換基を有するインドロキノキサリン類
Document Type and Number:
Japanese Patent JPH07103121
Kind Code:
B2
Abstract:
Novel indoloquinoxalines having substituents in 6-position containing cyclic groups, of the general formula I
wherein R1 represents hydrogen or one or several preferably 1 to 4, similar or different substituents in the positions 1-4 and/or 7-10, selected from halogen, lower alkyl-/alkoxy group having not more than 4 carbon atoms, trifluoromethyl group, trichloromethyl group;
X is a group
wherein Y is CH2, NH, O or S and a is 2, 3 or 4 and wherein also the bond -C=N- can be saturated; Z is alkyl having 1-6 carbon atoms, Cl, Br or CF3 and
R3 represents hydrogen, lower alkyl-/cykloalkyl group having not more than 4 carbon atoms,
and the physiologically acceptable addition products of the compounds with acids and halogen adducts are described. Also methods for preparing said compounds by reaction of a compound of the formula II
with a reactive compound containing the residue -CHR3X or by rearranging a compound of the formula III
by heating, are described.
The novel indoloquinoxalines have antiviral effect and have effect against cancer.
Inventors:
Bergmann, Jan Olof Einer
Okerfeld, Stig Gustav
Okerfeld, Stig Gustav
Application Number:
JP50075587A
Publication Date:
November 08, 1995
Filing Date:
January 19, 1987
Export Citation:
Assignee:
Lund Blood, Raif
International Classes:
A61K31/495; A61P31/12; C07D487/00; A61P35/00; C07D487/04; (IPC1-7): C07D487/04
Attorney, Agent or Firm:
Akira Asamura (3 outside)
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