【発明の名称】新規3―置換セフェム化合物及びその製造方法

Japanese Patent JPH0733389

B2

PCT No. PCT/KR91/00012 Sec. 371 Date Feb. 26, 1992 Sec. 102(e) Date Feb. 26, 1992 PCT Filed Apr. 19, 1991 PCT Pub. No. WO92/00981 PCT Pub. Date Jan. 23, 1992.The present invention relates to novel cephalosporins of the formula (I); (I) wherein, R1 represents a C1 DIFFERENCE C4 alkyl group or wherein, R2 and R3, independently, represent hydrogen or a C1 DIFFERENCE C3 alkyl group and R4 represents hydrogen or a C1 DIFFERENCE C4 alkyl group; R1a represents hydrogen or an amino-protecting group; Q represents CH or N; and the formula represents a saturated or unsaturated heterocyclic group which contains 1 to 4 nitrogen atoms of which one is substituted with an amino group to form quaternary ammonium, and oxygen or sulfur, or a fused heterocyclic group thereof formed together with a substituted or unsubstituted benzene or an optional heterocyclic group, or a pharmaceutically acceptable salt thereof, to processes for preparing the same and to a pharmaceutical composition containing the same as an active ingredient. The compounds(1) according to the invention exhibit potent antibacterial activity and broad antibacterial spectrum against the Gram-positive strains including Staphylococcus as well as Gram-negative strains including Pseudomonas, and, therefore, are expected to be very useful in treatment of various diseases caused by bacterial infection in human beings and animals.

JPS59199692	BENZOTHIENYLGLYCYLCEPHALOSPORIN DERIVATIVE
WO/1996/038450	CEPHALOSPORIN ANTIBIOTICS

MUN CHI ZAN
PAKU SEE CHOON
KIMU MYON GUU
OO SHII HAN
IMU SON SUU
PAKU NAMU JUN
CHOI YAN KEI
SAN MUU ZE

JP50755691A

April 12, 1995

April 19, 1991

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DEE UN PHARM CO LTD

A61K31/545; A61K31/546; A61P31/04; C07D501/00; C07D501/04; C07D501/06; C07D501/46; (IPC1-7): C07D501/46; A61K31/545; C07D501/04; C07D501/06

Takashima Hajime

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