Title:
【発明の名称】人好中球エラスターゼの阻害剤としてのフエニレンジアルカノエート類の芳香族エステル類
Document Type and Number:
Japanese Patent JPH07502505
Kind Code:
A
Abstract:
Compounds of the formula (I) (II) or (III) wherein: R1, R2, R3 and R4, which may be the same or different, are selected from the group consisting of hydrogen, alkyl of 1-6 carbons, cycloalkyl of 3 to 6 carbons, alkenyl of 2-6 carbons, or together represent methylene groups -(CH2)n-where n is a whole number from 1 to 6, provided that R1 and R2 or R3 and R4 are not both hydrogen; R5 and R6, which may be the same or different, are selected from the group consisting of hydrogen, halogen, nitro or -S(O)nR7 where n is 0, 1 or 2 and R7 is an optionally substituted alkyl of 1-12 carbons atoms; and both Ar substituents are optionally substituted heteroaromatic rings or one Ar is such heteroaromatic ring and the other is optionally substituted phenyl, the optional substitution for Ar being halogen, nitro or -S(O)nR7 where n and R7 have the value given above. The compounds are useful as inhibitors of human neutrophil elastase.
Inventors:
Olexis Gin, Joseph
Kirchen Houter, Gary Pee.
Kirchen Houter, Gary Pee.
Application Number:
JP51095493A
Publication Date:
March 16, 1995
Filing Date:
December 01, 1992
Export Citation:
Assignee:
Co-Tech Incorporated
International Classes:
A61K31/215; A61K31/216; A61K31/505; A61K31/506; A61P9/10; A61P11/00; A61P29/00; A61P43/00; C07C69/65; C07D239/34; C07C69/773; C07C205/43; C07C315/02; C07C317/18; C07C317/22; C07C317/44; C07C319/20; C07C323/12; C07C323/18; C07C323/20; C07C323/50; C07C323/52; C07D239/28; C07D239/38; (IPC1-7): C07C69/65; A61K31/215; A61K31/505; C07C205/43; C07C315/02; C07C317/22; C07C319/20; C07C323/18; C07D239/34
Attorney, Agent or Firm:
Katsuro Sasai