Title:
【発明の名称】環式AMPホスホジエステラーゼ及び腫瘍壊死因子の阻害剤としての1-アルコキシ-(2-アルコキシ-またはシクロアルコキシ)-4-(シクロチオアルキル-またはシクロチオアルケニル)ベンゼン
Document Type and Number:
Japanese Patent JPH07504201
Kind Code:
A
Abstract:
PCT No. PCT/GB93/00445 Sec. 371 Date Nov. 3, 1994 Sec. 102(e) Date Nov. 3, 1994 PCT Filed Mar. 4, 1993 PCT Pub. No. WO93/18024 PCT Pub. Date Sep. 16, 1993This invention is directed to 1-alkoxy-2-(alkoxy- or cycloalkyloxy-)-4-(cyclothioalkyl- or cyclothioalkenyl-)benzene compounds that inhibit cyclic AMP phosphodiesterase or tumor necrosis factor (TNF) and are useful in treating patients suffering from disease state capable of being modulated by inhibiting production of cyclic AMP phosphodiesterase or TNF by administering the compound to the patient. The invention is also directed to the preparation of these compounds, pharmaceutical compositions containing these compounds and methods for their pharmaceutical use.
Inventors:
Fenton, Geary
Mason, The Jonathan Stephen
Parfleyman, Malcolm Norman
Ratcliff, Andrew The Ames
Mason, The Jonathan Stephen
Parfleyman, Malcolm Norman
Ratcliff, Andrew The Ames
Application Number:
JP51544693A
Publication Date:
May 11, 1995
Filing Date:
March 04, 1993
Export Citation:
Assignee:
Loan-Poulin Lore Limited
International Classes:
A61K31/38; A61K31/381; A61K31/382; A61P1/00; A61P11/00; C07D333/08; A61P13/02; A61P15/00; A61P17/00; A61P25/00; A61P25/04; A61P29/00; A61P31/04; A61P35/02; A61P37/00; A61P37/08; A61P43/00; C07D333/16; C07D333/32; C07D333/48; C07D335/02; (IPC1-7): C07D333/08; A61K31/38; C07D333/32; C07D333/48; C07D335/02
Attorney, Agent or Firm:
Heiyoshi Odashima