Title:
【発明の名称】フォン・ウィルブランド因子の治療用ドメイン
Document Type and Number:
Japanese Patent JPH07507270
Kind Code:
A
Abstract:
A polypeptide which is capable of inhibiting binding of von Willebrand factor (vWF) to platelets and comprising an amino acid sequence that corresponds to the amino acid sequence of that fragment of mature von Willebrand factor subunit having its amino terminus at about Cys509 and its carboxy terminus at about Cys695, said polypeptide comprising optionally a second and/or a third domain, the second domain corresponding to the amino acid sequence of that fragment of mature vWF subunit having its amino terminus at about Thr450 and its carboxy terminus at about Tyr508, or a subfragment or combination of subfragments thereof, and a third domain corresponding to the amino acid sequence of that fragment of mature vWF subunit having its amino terminus at about Asp696 and its carboxy terminus at about Gly727, or a subfragment or combination of subfragments thereof; and also a process for producing said polypeptides from encoding DNA sequences, and also a method of inhibiting or treating thrombosis in a patient which comprising administering to such patient an effective amount of a therapeutic composition comprising one or more polypeptides of the invention.
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Inventors:
Ruggeri Caverio Emme
Wear Jerry El
Wear Jerry El
Application Number:
JP51513693A
Publication Date:
August 10, 1995
Filing Date:
February 23, 1993
Export Citation:
Assignee:
THE SCRIPPS RESEARCH INSTITUTE
International Classes:
A61K38/43; A61K39/395; A61P7/02; C07K14/745; C07K14/755; C07K16/00; C07K16/36; C07K19/00; C12N1/21; C12N5/10; C12N15/12; C12P21/02; C12N15/09; A61K38/00; C12R1/19; C12R1/91; (IPC1-7): C07K14/745; A61K38/43; A61K39/395; C07K16/36; C12N1/21; C12N5/10; C12N15/09; C12P21/02
Attorney, Agent or Firm:
Minoru Nakamura (7 outside)