Title:
【発明の名称】高収量の組換え産物の産生宿主体
Document Type and Number:
Japanese Patent JPH0771483
Kind Code:
B2
Abstract:
This invention relates to improved host organisms and methods for producing recombinant products in high yields. More particularly, the present invention relates to cell strains carrying specific mutations within their DNA sequences which cause the organism to exhibit a reduced capacity for degrading foreign products and the use of these strains to produce increased yields of genetically engineered foreign proteins, polypeptides and other products. The methods disclosed in this invention advantageously permit the production, in high yields, of foreign recombinant proteins, polypeptides or other products in hosts which do not usually produce such products.
Inventors:
Goldberg, Alfred El
Goff, Stephen A
Kasson, Lawrence Pee
Goff, Stephen A
Kasson, Lawrence Pee
Application Number:
JP26902093A
Publication Date:
August 02, 1995
Filing Date:
October 27, 1993
Export Citation:
Assignee:
President and Fellows of Harvard College
International Classes:
A61K38/21; A61K38/46; A61P7/02; C07K14/65; C12N1/20; C12N1/21; C12N9/64; C12N9/72; C12N15/09; C12N15/67; C12N15/00; C12N15/70; C12P21/00; C12R1/19; (IPC1-7): C12N1/21; C12N15/09
Attorney, Agent or Firm:
Haruo Hamada
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