Title:
【発明の名称】TGF-βの中和による長期骨髄培養物における幹細胞の拡大
Document Type and Number:
Japanese Patent JPH08509859
Kind Code:
A
Abstract:
A method for expanding growth of hematopoietic stem cells in culture includes a step of admixing to the culture a TGF- beta antagonist such as a soluble TGF- beta receptor or a TGF- beta -neutralizing antibody. Also, treating an animal includes steps of admixing a TGF- beta antagonist to a culture of bone marrow cells to stimulate production of hematopoietic stem cells in the culture, and thereafter administering hematopoietic cells so produced to the animal. Also, a method for treating an animal includes steps of administering a TGF- beta antagonist to the animal.
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Inventors:
Wagel, Wendy
Dutch, james
Kincaid, Paul W.
Dutch, james
Kincaid, Paul W.
Application Number:
JP51908594A
Publication Date:
October 22, 1996
Filing Date:
February 15, 1994
Export Citation:
Assignee:
Sertrics Pharmaceuticals, Inc.
Oklahoma Medical Research Foundation
Oklahoma Medical Research Foundation
International Classes:
C12P21/08; A61K35/28; A61K38/00; A61K38/17; A61K38/22; A61K39/395; A61P7/00; C07K16/22; C12N5/0789; A61K35/12; (IPC1-7): C12N5/06; A61K38/00; A61K39/395
Attorney, Agent or Firm:
Shusaku Yamamoto