Title:
【発明の名称】特に神経変性疾患の治療のための医薬組成物およびその使用
Document Type and Number:
Japanese Patent JPH09503915
Kind Code:
A
Abstract:
Use of a cpd. (A) that at least partly inhibits the activity of p53 protein to prepare a compsn. for treating and/or preventing neurodegenerative diseases is new. Also claimed is recombinant virus contg., inserted in its genome, nucleic acid (a) encoding a mutated form of p53 able to antagonise p53 activity; (b) contg. all or part of the p53 binding site and/or (c) encoding antisense material able to reduce p53 expression at translational or transcriptional levels.
Inventors:
Male, Jack
Leva, Frederik
Steutzman, Jiang-Marie
Leva, Frederik
Steutzman, Jiang-Marie
Application Number:
JP51063995A
Publication Date:
April 22, 1997
Filing Date:
September 29, 1994
Export Citation:
Assignee:
Loan-Poulin L'Oré Societe Anonym
International Classes:
C12N15/09; A61K31/70; A61K31/713; A61K48/00; A61P25/00; A61P25/08; A61P25/28; A61P43/00; C07K14/82; C12N7/00; C12N7/01; C12N15/113; C12N15/86; C12N15/861; A61K38/00; (IPC1-7): C12N15/09; A61K31/70; A61K48/00; C07K14/82; C12N7/00
Attorney, Agent or Firm:
Heiyoshi Odashima