Title:
【発明の名称】5HT1D拮抗薬として有用な複素環式ビフェニリルアミド類
Document Type and Number:
Japanese Patent JPH09506101
Kind Code:
A
Abstract:
PCT No. PCT/EP94/03948 Sec. 371 Date Jun. 7, 1996 Sec. 102(e) Date Jun. 7, 1996 PCT Filed Nov. 28, 1994 PCT Pub. No. WO95/15954 PCT Pub. Date Jun. 15, 1995A compound of formula (I) or a salt thereof: membered heterocyclic ring selected from the group consisting of thienyl, furyl, pyrrolyl, triazolyl, diazolyl, tetrazolyl, imidazolyl, oxadiazolyl, isothiazolyl, isoxazolyl, thiadiazolyl, pyridyl, pyrimdyl and pyrazinyl; R1, R2 and R3 are independently hydrogen, halogen, C1-6 alkyl, C3-6 cycloalkyl, C3-6 cycloalkenyl, C1-6 alkoxy, hydroxyC1-6 alkyl, C1-6 alkylOC1-6 alkyl, alkanoyl, optionally substituted phenyl, alkanoyloxy, hydroxy, nitro, trifluoromethyl, cyano, CO2R9,CONR10R11 where R9, R10 and R11 are independently hydrogen or C1-6 alkyl; R4 and R5 are independently hydrogen or C1-6 alkyl; R6 is hydrogen, halogen, hydroxy, C1-6 alkyl or C1-6 alkoxy R7 and R8 are independently hydrogen, C1-6 alkyl, a optionally substituted phenylalkyl or together with the nitrogen atom to which they are attached form an optionally substituted 5- to 7-membered heterocyclic ring containing one or two heteroatoms selected from oxygen, nitrogen or sulphur; A is CONH or NHCO; B is oxygen, S(O)p where p is 0, 1 or 2, NR12 where R12 is hydrogen, C1-6 alkyl or phenylC1-6 alkyl, or B is CR4=CR5 or CR4R5 where R4 and R5 are independently hydrogen or C1-6 alkyl; m is 1 to 4; and n is 1 or 2.
Inventors:
Gaster, Laramie Mary
Francis David, King
Wyman, Paul Adrian
Francis David, King
Wyman, Paul Adrian
Application Number:
JP51594095A
Publication Date:
June 17, 1997
Filing Date:
November 28, 1994
Export Citation:
Assignee:
SmithKline Beecham Public Limited Company
International Classes:
A61K31/34; A61K31/341; A61K31/40; A61K31/41; A61K31/42; A61K31/4245; A61K31/425; A61K31/426; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4418; A61K31/445; A61K31/495; A61K31/496; A61K31/505; A61K31/535; A61K31/5377; A61P5/00; A61P9/12; A61P13/02; A61P15/00; A61P25/00; A61P25/18; A61P25/24; A61P25/26; A61P25/28; C07D213/56; C07D239/26; C07D241/12; C07D249/08; C07D257/04; C07D261/08; C07D271/06; C07D271/107; C07D277/28; C07D277/30; C07D307/38; C07D413/12; C07D521/00; C07D271/10; (IPC1-7): C07D213/56; A61K31/34; A61K31/40; A61K31/41; A61K31/42; A61K31/425; A61K31/44; A61K31/445; A61K31/495; A61K31/505; A61K31/535; C07D239/26; C07D241/12; C07D249/08; C07D257/04; C07D261/08; C07D271/06; C07D277/28; C07D307/38; C07D413/12
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)