Title:
マウス細胞のための相同的組換え抗体発現系
Document Type and Number:
Japanese Patent JPH09510865
Kind Code:
A
Abstract:
A specific locus in the genome of a murine host cell is identified which causes high levels of recombinant gene expression following stable integration, via homologous recombination, of the recombinant gene into the specific chromosomal locus. The selection of a favorable genome locus for the insertion and expression of a recombinant gene is disclosed, as are DNA vectors and host cells.
Inventors:
ホリス， グレゴリー フランクリン
マーク， ジョージ イー．
マーク， ジョージ イー．
Application Number:
JP51730195A
Publication Date:
November 04, 1997
Filing Date:
December 22, 1994
Export Citation:
Assignee:
メルク アンド カンパニー， インコーポレイテッド
International Classes:
C12N15/09; C07K16/00; C12N5/10; C12N15/85; C12N15/90; C12P21/02; (IPC1-7): C12N15/09; C12P21/02
Attorney, Agent or Firm:
山本 秀策