Title:
【発明の名称】1,1′-〔1,4-フェニレンビス-(メチレン)〕-ビス-1,4,8,11-テトラアザシクロテトラデカンを調製するための方法
Document Type and Number:
Japanese Patent JPH11504917
Kind Code:
A
Abstract:
An improved process for preparing 1,1'-[1,4-phenylenebis-(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane comprising the selective functionalization of an acyclic tetraamine to obtain an acyclic ditosyl intermediate and an acyclic tritosyl intermediate in a first step, the independent dimerization/tosylation of the ditosyl intermediate and dimerization of the tritosyl intermediate to obtain a 1,4-phenylenebis-methylene bridged hexatosyl acyclic precursor in a second step, the cyclization of said precursor to obtain a hexatosyl cyclam dimer in a third step, and the detosylation of said cyclam dimer in a fourth step followed by basification to obtain the desired 1,1'-[1,4-phenylenebis-(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane.
Inventors:
Prashad, Mahavia
Kapa, Prasad
Kapa, Prasad
Application Number:
JP53315896A
Publication Date:
May 11, 1999
Filing Date:
April 23, 1996
Export Citation:
Assignee:
Johnson Massey Public Limited Company
International Classes:
C07C311/18; C07D257/02; (IPC1-7): C07C311/18; C07D257/02
Attorney, Agent or Firm:
Takashi Ishida (3 others)