Japanese Patent JPS4939256

B1

1,274,652. Antidepressant &c. compositions. LILLY INDUSTRIES Ltd. 28 Oct., 1969 [27 Aug., 1968], No. 40968/68. Heading A5B. [Also in Division C2] Pharmaceutical compositions having antidepressant, -Parkinsonism and -motion sickness and appetite suppressant activity comprise, as active ingredient, at least one 1-aminoalkyladamantane of the general formula wherein n is 1 or 2; R1 is a hydrogen atom or a C 1-4 alkyl group or, when n is 1, R1 and R4 together form a methylene group; R2 is a hydrogen atom or C 1-4 alkyl group or, when n is 1, a C 1-4 hydroxyalkyl or phenyl-C 1- 4 alkyl group, R3 is a hydrogen atom or a C 1-4 alkyl group or, when R2 is a hydrogen atom, R3 is an amidino, pyrimidinyl or C 1-4 alkylpyrimidinyl group, or NR2R3 is a pyrrolidino, piperidino, NC 1-4 alkylpiperazino or N-C 1-4 hydroxyalkylpiperazino group; R4 is a hydrogen or chlorine atom or a phenyl group or, when n is 1, a bromine atom or cyclohexyl group; R5 and R6 are each a hydrogen atom or, when n is 1, a chlorine atom or phenyl group; provided that one of R4, R5 and R6 is not a chlorine atom and the others are hydrogen atoms or R4 is not a bromine atom and R5 and R6 are hydrogen atoms, when R7, R8 and R9 are hydrogen atoms, R1 is a hydrogen atom or a C 1-4 alkyl group, one of R2 and R3 is a hydrogen atom and the other is a C 1-4 alkyl group and n is 1; R7 is a hydrogen or bromine atom or a hydroxyl or -(CH 2 ) n - -CHR a 1-NR a 2R a 3 group, wherein n is 1 or 2 and R a 1, R a 2 and R a 3 are each a hydrogen atom or a C 1-4 alkyl group, or, when n is 1, R7 is a methyl group; and R8 and R9 are each a hydrogen atom or, when n is 1, a methyl group; or pharmaceutically acceptable acid addition salt thereof, in association with a pharmaceutically acceptable carrier.

JP6456272A

October 24, 1974

June 29, 1972

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C07D295/02; A61K31/13; A61K31/135; A61P25/26; A61P43/00; B01J19/12; B01J21/00; C07B61/00; C07C53/138; C07C53/44; C07C55/38; C07C67/00; C07C209/00; C07C209/28; C07C209/50; C07C209/54; C07C211/19; C07C211/39; C07C211/44; C07C213/00; C07C215/08; C07C215/42; C07D239/42; C07D295/03; (IPC1-7): C07C87/40

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