Title:
【発明の名称】ハロビンカモン誘導体の製造方法
Document Type and Number:
Japanese Patent JPS5822154
Kind Code:
B2
Abstract:
The invention relates to new halovincamone derivatives of the general formula (I), (I) wherein R is a C1-6 alkyl group and X is halogen, and pharmaceutically acceptable acid addition salts and optically active isomers thereof. These compounds possess valuable vasodilating effect, and can be applied to advantage in the therapy. The new compounds defined above are prepared according to the invention so that a single epimer or an epimeric mixture of a racemic or optically active halogenated 14-oxo-15-hydroxy-E-homoeburnane derivative of the general formula (II), (II) wherein R and X are as defined above, or an acid addition salt thereof is treated with an oxidizing agent, and, if desired, the resulting compound of the general formula (I) is converted into its pharmaceutically acceptable acid addition salt and/or resolved.
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Inventors:
CHABA SANTAI
RAIOSU SABO
JERUJI KARAUSU
RAIOSU DANCHII
CHIBORU KEBE
FUERENKO DOREKUSURERU
RAIOSU SABO
JERUJI KARAUSU
RAIOSU DANCHII
CHIBORU KEBE
FUERENKO DOREKUSURERU
Application Number:
JP10724280A
Publication Date:
May 06, 1983
Filing Date:
August 06, 1980
Export Citation:
Assignee:
RIHITAA GEDEON BEGIESUZECHI GIARU AARU TEII
International Classes:
A61K31/435; A61P9/08; C07D461/00; (IPC1-7): C07D461/00
Attorney, Agent or Firm:
Aoki Akira