Title:
【発明の名称】α-アスパルチルフエニルアラニンメチルエステルの製造方法
Document Type and Number:
Japanese Patent JPS58501909
Kind Code:
A
Abstract:
PCT No. PCT/FR82/00181 Sec. 371 Date Jul. 5, 1983 Sec. 102(e) Date Jul. 5, 1983 PCT Filed Nov. 5, 1982 PCT Pub. No. WO83/01619 PCT Pub. Date May 11, 1983.The present invention relates to a process for the preparation of alpha -aspartyl phenylalanine methyl ester by reacting phenylalanine methyl ester with the anhydride of N-formyl L-aspartic acid, process wherein the product from said reaction is treated in at least one ion-exchanging resin column and the beta -isomer contained in the resulting mixture is isomerized by treatment with acetic anhydride followed by an acid hydrolysis to convert said beta -isomer into alpha -isomer and ensure the deformylation of said product.
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Inventors:
Gobault Maurice Jean
Application Number:
JP50329482A
Publication Date:
November 10, 1983
Filing Date:
November 05, 1982
Export Citation:
Assignee:
LABORA Toiles Fornia-S-E-
International Classes:
C07K1/02; A23L27/30; C07C227/34; C07C229/34; C07K1/10; C07K1/113; C07K1/12; C07K1/14; C07K5/06; C07K5/075; (IPC1-7): C07C103/52
Domestic Patent References:
| JPS5494385A | 1979-07-26 | |||
| JPS5494384A | 1979-07-26 | |||
| JPS57142523A | 1982-09-03 |
Foreign References:
| US3931521A | 1976-01-06 | |||
| US3825754A | 1974-07-23 |
Attorney, Agent or Firm:
Takehiko Suzue