Title:
P38キナーゼの阻害剤および/または炎症治療のためのTNF阻害剤としての1-(2H-ピラゾール-3-イル)-3-{4-[1-(ベンゾイル)-ピペリジン-4-イルメチル]-フェニル}-ウレア誘導体および関連化合物
Document Type and Number:
Japanese Patent JP4714150
Kind Code:
B2
Abstract:
The present invention provides compounds of Formula (I) and ester prodrugs, pharmaceutically acceptable salts or solvates of such compounds; or ester prodrugs of such salts or solvates; pharmaceutical compositions comprising such compounds, their preparation, and their pharmaceutical use in the treatment of disease states capable of being modulated by the inhibition of p38 kinase and/or tumor necrosis factor (TNF).
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Inventors:
David Earl Bocharding
Alexander Gross
Patrick Wy-Kwok Sham
Nicole Willard
Brian S Freed
Alexander Gross
Patrick Wy-Kwok Sham
Nicole Willard
Brian S Freed
Application Number:
JP2006532565A
Publication Date:
June 29, 2011
Filing Date:
May 05, 2004
Export Citation:
Assignee:
Aventis Pharmaceuticals Incorporated
International Classes:
C07D401/12; A61K31/454; A61K31/46; A61P3/10; A61P9/10; A61P11/00; A61P11/06; A61P19/02; A61P25/04; A61P27/02; A61P29/00; A61P35/00; A61P43/00; C07D401/14; C07D405/14; C07D409/14; C07D413/14; C07D417/14; C07D451/02; C07D471/04
Attorney, Agent or Firm:
Chika Takagi
Junji Yuda
Shoji Miwa
Junji Yuda
Shoji Miwa