Title:
1-Ally Lu 4-methyl [1, 2, 4] triazolo [4 and 3-] [a] quinoxaline derivative
Document Type and Number:
Japanese Patent JP6115962
Kind Code:
B2
Abstract:
The present invention relates to novel 1-aryl-4-methyl-[1,2,4]triazolo[4,3-a]-quinoxaline derivatives as inhibitors of phosphodiesterase 2 (PDE2) and to a lesser extent of phosphodiesterase 10 (PDE10) or as inhibitors of both, phosphodiesterases 2 and 10. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which PDE2 is involved, or disorders in which both PDE2 and PDE10 are involved, such as neurological and psychiatric disorders, and endocrinological or metabolic diseases. The present invention also relates to radiolabelled compounds which may be useful for imaging and quantifying the PDE2 enzyme in tissues, using positron-emission tomography (PET). The invention is also directed to compositions comprising such compounds, to processes for preparing such compounds and compositions, to the use of such compounds and compositions for imaging a tissue, cells or a host, in vitro or in vivo and to precursors of said compounds.
Inventors:
Andre Jill, Jose Ignacio
Buinsters, Peter Jacobs Johannes Antonius
Travanco-Suarez, Andres Avellino
De Angielis, Meri
Banhof, Greta Constantia Peter
Guilmon, Jerome Emile Giorgiuille
Ron boots, Frederik Jiang Rita
Bregen, Marten
Bormann, Gui Maurits Earl
Selenium, Sophie Jeanne Leopoldine
Buinsters, Peter Jacobs Johannes Antonius
Travanco-Suarez, Andres Avellino
De Angielis, Meri
Banhof, Greta Constantia Peter
Guilmon, Jerome Emile Giorgiuille
Ron boots, Frederik Jiang Rita
Bregen, Marten
Bormann, Gui Maurits Earl
Selenium, Sophie Jeanne Leopoldine
Application Number:
JP2014517667A
Publication Date:
April 19, 2017
Filing Date:
June 26, 2012
Export Citation:
Assignee:
Janssen Pharmaceuticals N.B.
International Classes:
C07D487/04; A61K31/4985; A61K31/5377; A61P3/04; A61P3/06; A61P3/10; A61P25/00; A61P25/04; A61P25/14; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/30; A61P25/32; A61P25/36
Foreign References:
| WO2010138833A1 |
Other References:
European Journal of Medicinal Chemistry,2009年,44,pp.1135-1143
Indian Journal of Heterocyclic Chemistry,2006年,16,pp.1-4
Indian Journal of Heterocyclic Chemistry,2005年,14,pp.361-362
Indian Journal of Heterocyclic Chemistry,2006年,16,pp.1-4
Indian Journal of Heterocyclic Chemistry,2005年,14,pp.361-362
Attorney, Agent or Firm:
Hiroshi Kobayashi
Eiji Katayama
Junko Kobayashi
Norio Omori
Yasuhito Suzuki
Patent business corporation Odashima patent office
Eiji Katayama
Junko Kobayashi
Norio Omori
Yasuhito Suzuki
Patent business corporation Odashima patent office
Previous Patent: Art for processing network traffic
Next Patent: HEATER COIL FOR VAPOR DEPOSITION OF METAL BACK OF CATHODE RAY TUBE
Next Patent: HEATER COIL FOR VAPOR DEPOSITION OF METAL BACK OF CATHODE RAY TUBE