1,6-DI-SUBSTITUTED INDANE DERIVATIVE AND ANTIHELICOBACTER PYLORI AGENT

Title:

1,6-DI-SUBSTITUTED INDANE DERIVATIVE AND ANTIHELICOBACTER PYLORI AGENT

Document Type and Number:

Japanese Patent JPH1072390

Kind Code:

A

Abstract:

To obtain the subject new compound having antibacterial activity which is specific to Helicobacter pylori and capable of expecting uses as a selective antibacterial agent.

This 1,6-di-substituted indane derivative is represented by formula I [R1 is a substituted or unsubstituted aryl or lower alkyl; R2 is hydroxymethyl or carboxyl; (n) is an integer of 2-10], e.g. 6-benzyl-1-(3- carboxypropyl)indane. The compound of formula I in which R1 is phenyl is obtained by using terephthalaldehyde acid methyl as a starting material to synthesize 6-benzyl-1-[4-(t-butyldimethylsilyl-oxy)butyl]indane, deprotecting 4-(4- butyldimethylsilyloxy)butyl group therefrom, further oxidizing the deprotected compound. This antihelicobacter pylori agent can be obtained from the indane derivative.

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Inventors:

NUMAO OSANORI
IWABORI AKIYO
HIROTA YUMIKO
KOBAYASHI SUSUMU
TAKAO KENICHI

Application Number:

JP22859296A

Publication Date:

March 17, 1998

Filing Date:

August 29, 1996

Export Citation:

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Assignee:

SAGAMI CHEM RES

International Classes:

A61K31/045; A61K31/19; A61P31/04; C07C33/34; C07C57/50; (IPC1-7): C07C33/34; A61K31/045; A61K31/19; C07C57/50

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