Title:
（１Ｓ）−４−［４−（ジメチルアミノ）−１−（４’−フルオロフェニル）−１−ヒドロキシブチル］−３−（ヒドロキシメチル）−ベンゾニトリルヘミ（＋）−ジ−（ｐ−トルオイル）酒石酸塩の製造方法、及び該酒石酸塩を用いた（１Ｓ）−１−［３−（ジメチルアミノ）プロピル］−１−（４−フルオロフェニル）−１，３−ジヒドロイソベンゾフラン−５−カルボニトリル及びその塩の製造方法
Document Type and Number:
Japanese Patent JP6815853
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To provide a production process in which (1S)-4-[4-(dimethylamino)-1-(4'-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)-benzonitrile hemi(+)-di-(p-toluoyl) tartaric acid salt that has extremely high chemical purity and optical purity is obtained in high yield.SOLUTION: Provided is a production process characterized in producing a tartaric acid salt as a crystallized product by reacting racemate 4-[4-(dimethylamino)-1-(4'-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)-benzonitrile with (+)-di-(p-toluoyl) tartaric acid to yield (1S)-4-[4-(dimethylamino)-1-(4'-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)-benzonitrile hemi(+)-di-(p-toluoyl) tartaric acid salt and followed by carrying out crystallization of the tartaric acid salt with a solvent containing 1-butanol.SELECTED DRAWING: None
Inventors:
Yoshio Yokoo
Nozomi Yamada
Takayuki Miyaoku
Nozomi Yamada
Takayuki Miyaoku
Application Number:
JP2016234305A
Publication Date:
January 20, 2021
Filing Date:
December 01, 2016
Export Citation:
Assignee:
Tokuyama Corporation
International Classes:
C07C253/34; C07C255/59; C07D307/87
Foreign References:
| CN1173929C |
Other References:
インド国特許第2005DE02524号明細書