Title:
2'-DEOXY-3',5'-DI-O-ACETYL-5-FLUOROURIDINE DERIVATIVE, ITS PREPARATION AND ANTITUMOR AGENT CONTAINING THE SAME
Document Type and Number:
Japanese Patent JPS56113795
Kind Code:
A
Abstract:
NEW MATERIAL:The titled compound expressed by the formula (R is heterocyclic ring residue).
EXAMPLE: 3-(Furan-2-carbonyl)-2'-deoxy-3',5'-di-O-acetyl-5-fluorouridine.
USE: An antitumor agent with low toxicity and a powerful antitumor activity.
PROCESS: 2'-Deoxy-3',5'-di-O-acetyl-5-fluorouridine is reacted with an acid halide, e.g. chloride or bromide, of the formula R-CO-hal (hal is halogen) in a solvent, e.g. ether or chloroform, preferably in the presence of a base, e.g. a trialkylamine or pyridine, to give the compound of the formula.
Inventors:
FUJII SETSUO
YASUI BONPEI
FUKAMI HIDEO
SAKO YOSHITAKA
MIYAMOTO TOMOHISA
ANDOU KAZUKO
HASHIMOTO IWAO
KURA YONEICHI
KAWAI SHIYOUICHIROU
MIYAGAWA YUMIKO
YASUI BONPEI
FUKAMI HIDEO
SAKO YOSHITAKA
MIYAMOTO TOMOHISA
ANDOU KAZUKO
HASHIMOTO IWAO
KURA YONEICHI
KAWAI SHIYOUICHIROU
MIYAGAWA YUMIKO
Application Number:
JP1613780A
Publication Date:
September 07, 1981
Filing Date:
February 13, 1980
Export Citation:
Assignee:
FUNAI PHARMACEUTICAL IND LTD
International Classes:
C07H19/073; A61K31/70; A61K31/7042; A61K31/7052; A61K31/7064; A61K31/7072; A61P35/00; C07H19/06; (IPC1-7): A61K31/70; C07H19/06
Domestic Patent References:
JPS54163586A | 1979-12-26 |
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