Title:
翻訳開始阻害剤としての3-3-二置換オキシインドール
Document Type and Number:
Japanese Patent JP4989976
Kind Code:
B2
Abstract:
Compositions and methods for inhibiting translation using 3-(5-tert-Butyl-2-Hydroxy-phenyl)-3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, and/or (4) disorders associated with viral infections, using 3-(5-tert-butyl-2-hydroxy-phenyl)-3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are described.
Inventors:
Harperin Jose A.
Natarajan Amanas
Actus Hussein
Fan Yun-fa
Chen Han
Natarajan Amanas
Actus Hussein
Fan Yun-fa
Chen Han
Application Number:
JP2006553263A
Publication Date:
August 01, 2012
Filing Date:
February 11, 2005
Export Citation:
Assignee:
President and Fellows of Harvard College
International Classes:
C07D209/34; A61K31/404; A61K31/4178; A61K31/427; A61P31/12; A61P35/00; A61P43/00; C07D403/04; C07D409/04; C07D417/10; C07D498/08
Domestic Patent References:
| JP50154242A | ||||
| JP55129284A |
Foreign References:
| WO2003078394A1 | ||||
| US5849780 |
Other References:
BARKER, MARVIN W.,Oxindoles from .alpha.-acyloxyamides,JOURNAL OF HETEROCYCLIC CHEMISTRY,1977年,14(3),521-2
PETYUNIN, P. A. ,Chemistry of heterocycles. LIII. Case of deamination during the acidochromic cyclization of arylamides of diarylglycolic acids,KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII ,1972年,(2),182-3
BOLOTOV, V. V. ,Synthesis and antiinflammatory activity of 3,3-diphenyl-2-oxoindolinecarboxylic acids and their amides,KHIMIKO-FARMATSEVTICHESKII ZHURNAL,1980年,14(12),39-42
Shoichet, Brian K. ,Structure-based discovery of inhibitors of thymidylate synthase,Science (Washington, DC, United States) ,1993年,259(5100),1445-50
PETYUNIN, P. A. ,Chemistry of heterocycles. L. Aminoalkylation or 3,3-disubstituted oxindoles,FARMATSEVTICHNII ZHURNAL (KIEV),1973年,28(3),23-6
BOLOTOV, V. V. ,Synthesis and antiinflammatory activity of 3,3-disubstituted 2-oxoindoline-1-acetic acids and their derivatives,KHIMIKO-FARMATSEVTICHESKII ZHURNAL ,1979年,13(11),45-9
OGATA, MASARU ,Synthesis and antimycotic properties of 3-(1-imidazolyl)indolin-2-ones,EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,1981年,16(4),373-8
PETYUNIN, P. A. ,Chemistry of heterocycles. LIII. Case of deamination during the acidochromic cyclization of arylamides of diarylglycolic acids,KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII ,1972年,(2),182-3
BOLOTOV, V. V. ,Synthesis and antiinflammatory activity of 3,3-diphenyl-2-oxoindolinecarboxylic acids and their amides,KHIMIKO-FARMATSEVTICHESKII ZHURNAL,1980年,14(12),39-42
Shoichet, Brian K. ,Structure-based discovery of inhibitors of thymidylate synthase,Science (Washington, DC, United States) ,1993年,259(5100),1445-50
PETYUNIN, P. A. ,Chemistry of heterocycles. L. Aminoalkylation or 3,3-disubstituted oxindoles,FARMATSEVTICHNII ZHURNAL (KIEV),1973年,28(3),23-6
BOLOTOV, V. V. ,Synthesis and antiinflammatory activity of 3,3-disubstituted 2-oxoindoline-1-acetic acids and their derivatives,KHIMIKO-FARMATSEVTICHESKII ZHURNAL ,1979年,13(11),45-9
OGATA, MASARU ,Synthesis and antimycotic properties of 3-(1-imidazolyl)indolin-2-ones,EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,1981年,16(4),373-8
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi